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The impulse initiates in a small bundle of special cells found in the right atrium it is known as the SA node. Specialized cells depolarize during phase 3 but ventricular and atrial muscle cells do not. Pin On Heart Healthy Sometimes the SA node is called the natural pacemaker of the heartThe SA node sends electrical impulses at some level but depending on physical requirements stress or hormonal variables heart rate. . It produces the electrical impulses that cause your heart to beat. Specialized cells depolarize during phase 4 but ventricular and atrial muscle cells do not. C atrioventricular AV bundle bundle of His D atrioventricular AV node. Which of the following is often called the pacemaker of the heart. - HR is set by the SA node pacemaker modified by antagonistic influences of the ANS Hormones - Changes in HR are referred to as chronotropic effects o Positive chronotropic effect increase in HR o Negative chronotro...